Syndromic Craniosynostosis

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Genetic analysis of non-syndromic craniosynostosis.

Craniosynostosis is a common malformation occurring in 3-5 per 10,000 live births. Most often craniosynostosis occurs as an isolated (i.e. non-syndromic) anomaly. Non-syndromic craniosynostosis (NSC) is a clinically and genetically heterogeneous condition that has the characteristics of a multifactorial trait. It is believed that each sutural synostosis (e.g. sagittal, coronal) represents a dif...

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post-operative neurodevelopmental findings in syndromic and non-syndromic craniosynostosis

objective to evaluate the developmental situation of children that undergo operation because of syndromic and non-syndromic craniosynostosis. materials & methods in this prospective study, 24 children (4 to 16 months of age) who underwent neurosurgeryical intervention because of non-syndromic (79%) and syndromic (21%) craniosynostosis were recruited. for psychological evaluation, the bayley sca...

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Comparison of Periodontal Parameters in Individuals with Syndromic Craniosynostosis

Craniosynostosis syndromes are characterized by premature closure of one or more cranial sutures, associated with other malformations, the most frequent of which are the Crouzon and Apert syndromes. Few studies in the literature have addressed the oral health of these individuals. The purpose of this study was to compare the periodontal status of individuals with Apert, Crouzon, Pfeiffer and Sa...

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Genotypic and phenotypic analyses of Korean patients with syndromic craniosynostosis.

To the Editor : Craniosynostosis, the premature fusion of one or more cranial sutures, is a common malformation occurring in approximately 1 in 2500 live births (1), and ocular hypertelorism, proptosis, beaking of the nose and midface hypoplasia are the common facial features of the craniosynostosis (2, 3). The syndromic craniosynostosis is the hereditary form of craniosynostosis, which is asso...

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Fibroblast Growth Factor Receptor 2 (FGFR2) Mutation Related Syndromic Craniosynostosis

Craniosynostosis results from the premature fusion of cranial sutures, with an incidence of 1 in 2,100-2,500 live births. The majority of cases are non-syndromic and involve single suture fusion, whereas syndromic cases often involve complex multiple suture fusion. The fibroblast growth factor receptor 2 (FGFR2) gene is perhaps the most extensively studied gene that is mutated in various cranio...

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ژورنال

عنوان ژورنال: Seminars in Plastic Surgery

سال: 2012

ISSN: 1535-2188,1536-0067

DOI: 10.1055/s-0032-1320064